DESCRIPTION

Sen-Sei-Ro Liquid Gold™, a dietary supplement containing an exclusive all-natural, standardized extract of the Kyowa's cultured Agaricus blazei Murill mushroom is primarily used to reduce symptoms of fatigue, to promote vitality, overall well-being, and to support immune functions. ^**/* Normal immune function can decline with age, and are necessary for maintenance of vitality, energy, good health, and quality of life. A few major biomarkers for decreased immune functions are decreased natural killer cell (NK) activity, and the number of lymphocytes and macrophage cells. These cells, primarily attack diseased cells and thereby, maintain body homeostasis, promote health and quality of life. For the past half a century in Brazil and other countries, Agaricus blazei Murill mushroom has been used to restore vitality, and energy, and to serve as a potent tonic conducive to general health and aging concerns. ^**/*

CLINICAL TRIALS

The effectiveness of ABMK22 in Sen-Sei-Ro Gold™ and Sen-Sei-Ro Royal™ for health benefits were tested in several controlled pre- and clinical trials in animals and in humans. ^**/* Recent studies in Japan led researchers to report that in humans, ABMK22 in Sen-Sei-Ro Gold™ and Sen-Sei-Ro Royal™ enhanced NK cell activity, promoted maturation and activation of dendritic cells indicated by increased cell kill, elevated expression of CD80 and CD83 expressions (Biotherapy 15(4): 503-507, 2001), increased the number of macrophage (Anticancer Research 17(1A): 274-284, 1997; Japanese Association of Cancer Research, no. 2268, 1999) and tumor necrosis factor (alpha) (TNF-(alpha))(Japanese Association of Cancer Research, no. 1406, 1999; Japanese J. Veterinary Clin. Medicine 17(2):31-42, 1998). ^**/* Further clinical studies with Sen-Sei-Ro Gold™ and Sen-Sei-Ro Royal™ among 100 cancer patients undergoing chemotherapy in Korea have shown that NK cell activity were significantly enhanced, while NK cell activity in the placebo group was markedly diminished (Int. J. Gynecol. Cancer 14: 589-594, 2004). ^**/* Earlier and recent both pre- and clinical studies in Japan, and Korea, led researchers to report that Kyowa's Agaricus blazei Murill mushroom extract can be part of an effective treatment for supporting the immune systems of cancer patients by stimulating host defense system (Biotherapy 15(4): 503-507, 2001; Carbohydrate Res. 186(2): 267-273, 1989; Japanese J. Pharmacology 662: 265-271, 1994; Agricultural and Biological Chemistry 54: 2889-2905, 1990). ^**/*

INGREDIENTS

Each 100 ml heat-treated high pressure pack of all natural Kyowa's Agaricus blazei Murill water extract is scientifically standardized to contain 300mg% carbohydrate, 700mg% protein, 0mg% fat,; 1.4mg% sodium, 0% food quality cellulose, and 4 Kcal energy.

Molecular weights of polysaccharopeptides ranges between 600~8,000. Water: 99.2g%,; includes a variety of amino acids and vitamins (arginine 12mg%, lysine 6mg%, histidine 2mg%, phenylalanine 4mg%, tyrosine 4mg%, leucine 5mg%, isoleucine 3mg%, methionine 1mg%, valine 5mg%, alanine 13mg%, glycine 7mg%, proline 13mg%, glutamic acid 53mg%, serine 6mg%, threonine 5mg%, and asparagine 10mg%.

RECOMMENDED USE

As a dietary supplement, take 1~3 packs per day. Pour the liquid content into a cup or drink directly from the pack. Do not heat the pack either in a microwave oven or heating range or leave the pack open since the product does not contain any preservatives. If warming is necessary, place the pack in warm to mildly hot water for desired length of time. Once the pack is open, drink immediately.

ADVERSE REACTIONS

No subjects have reported any side effects since the dietary supplement was placed for consumers in Japan, and Korea for the past 10, and 5 years, respectively. The use of this dietary supplements (Sen-Sei-Ro Gold™, Royal™, and ABMK22) is generally safe based on FDA's INDA required tripartite genotoxicities, and 28-day subacute toxicity involving a comprehensive microscopic pathology of rats and dogs. In addition, two-year chronic toxicity studies of the product carried out by the Good Laboratory Practice (GLP) and American Association of Accreditation of Laboratory Animal Certification (AAALAC) certified Toxicology Research Center. Toxicity evaluation of general, CNS, reproductive and developmental, cardiovascular, immunology, and the two-year bioassay for carcinogenicity was negative. Recent clinical studies with 100 cancer patients undergoing chemotherapy in Korea have shown no known side effects or contraindications (Int. J. Gynecol. Cancer 14: 589-594, 2004). ^**/*

WARNINGS

Sen-Sei-Ro Liquid Gold™ and Sen-Sei-Ro Liquid Royal™ have not been evaluated in pregnant and breast feeding mothers or children and should consult a physician prior to use. Also consult a physician prior to use if taking a prescription medication. Keep this product out of the reach of children. Do not use if you are pregnant, can become pregnant or breast feeding.

HOW SUPPLIED

Sen-Sei-Ro Liquid Gold™ 100ml, and Sen-Sei-Ro Liquid Royal™ 50ml in water extract are high pressure heat sealed. A box contains 30, 100ml packs, and can be purchased directly from company representatives, health food stores, and independent pharmacies. Storage condition keep at room temperature and avoid any direct heat or sun light.

^**/* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

PRODUCT PHOTO(S):

NOTE: These photos can be used only for identification by shape, color, and imprint. They do not depict actual or relative size.

The product samples shown here have been supplied by the manufacturer and reproduced in full color by PDR as a quick-reference identification aid. While every effort has been made to assure accurate reproduction, please remember that any visual identification should be considered preliminary. In cases of poisoning or suspected overdosage, the drug's identity should be verified by chemical analysis.