Goodpasture's syndrome
Alternative names:
anti-glomerular basement membrane antibody disease; glomerulonephritis-pulmonary hemorrhage; lung purpura-glomerulonephritis; pulmonary - renal syndrome; rapidly progressive glomerulonephritis with pulmonary hemorrhage
Treatment:
Treatment is focused on slowing progression of the disease. It is most effective when begun early, before kidney function has deteriorated to the point of requiring dialysis. Corticosteroids or other anti-inflammatory agents may be used to reduce the immune response, with variable results. Immune suppressants such as cyclophosphamide or azathioprine are used aggressively to reduce immune system effects.
A procedure by which blood plasma, which contains antibodies, is removed from the body and replaced with fluids or donated plasma (plasmapheresis) may be performed daily for 2 or more weeks to remove circulating antibodies. It is fairly effective in slowing or reversing the disorder.
Dialysis may be required if kidney function is poor.
Kidney transplant may be quite successful, especially if performed after circulating antibodies have been absent for several months.
Expectations (prognosis):
The probable outcome is variable. Most cases progress to severe renal failure and end-stage renal disease within months. Early diagnosis and treatment makes the prognosis (probable outcome) more favorable.
Complications:
Calling your health care provider:
Call for an appointment with your health care provider if symptoms indicating Goodpasture's syndrome are present.
Call your health care provider if urine output decreases.
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