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Dubin-Johnson syndrome

Definition:

An inherited disorder characterized by mild jaundice throughout life.

Causes, incidence, and risk factors:

Dubin-Johnson syndrome is inherited as an autosomal recessive disorder. The transport of bilirubin from the liver into the biliary system is abnormal and the bilirubin accumulates in the liver. Affected people have life-long low-grade jaundice which may be aggravated by alcohol, pregnancy, infection, and other environmental factors.


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