Primary hyperaldosteronism

Alternative names:

Conn's syndrome; hyperaldosteronism

Definition:

A syndrome associated with increased secretion of the hormone aldosterone (see the aldosterone test) by the adrenal gland that is caused by an abnormality within the gland.

Causes, incidence, and risk factors:

Primary hyperaldosteronism is a rare condition. Most of the cases result from a benign tumor of the adrenal gland, which occurs more frequently in women, and is highest in those between 30 and 50 years old. The excess aldosterone secreted in this condition increases sodium reabsorption and potassium loss by the kidneys and results in electrolyte imbalances. Risk factors are being female and being between 30 and 50 years old. The incidence is 2 out of 100,000 people; fewer than 10 children have been reported in the literature with Conn's syndrome.