Testicular failure

Definition:

The inability of the testicles to produce sperm or male hormones.

Causes, incidence, and risk factors:

Causes of testicular failure include chromosomal abnormalities, testicular torsion, direct trauma to the testicles, diseases that affect the testicle (such as mumps orchitis and testicular cancer), and a variety of drugs. The condition is uncommon. Increased risk is associated with activities that may cause constant, low level trauma to the scrotum (such as riding a motorcycle) or frequent administration of a drug known to affect testicular function (such as heavy marijuana use or taking some prescription medications). Men who had an undescended testicle at birth are at higher risk.