Hemolytic-uremic syndrome (HUS)

Alternative names:

HUS

Treatment:

In both children and adults this is a serious complicating illness and death may occur. The treatment is supportive.

Transfusions of packed red cells and platelets are given as needed. Kidney dialysis may be indicated. Medications prescribed include corticosteroids and aspirin.

Plasmapheresis, also called plasma exchange, (or passage of the plasma through a Protein A filter) may be performed. The blood plasma (the portion that does not contain cells, but does contain antibodies) is removed and replaced with fresh (donated) plasma or filtered to remove antibodies from the circulation.

Expectations (prognosis):

About 60% of individuals receiving treatment will recover, and the outcome is better in children.

Complications:

• chronic or relapsing HUS
• acute renal failure
• Chronic renal failure
• uremia (symptoms caused by accumulation of nitrogen-containing wastes in the body)
• permanent neurologic losses
• perforation of the bowel
• seizures
• diabetes

Calling your health care provider:

Call your health care provider if symptoms of HUS develop. Decreased consciousness, blood in the stool, and absent urine output indicate an emergency situation.

Call your health care provider if you have experienced an episode of HUS and urine output decreases or other new symptoms develop.