Paroxysmal nocturnal hemoglobinuria (PNH)

Alternative names:

PNH

Treatment:

The objective of treatment is to stimulate new red blood cell formation. The administration of iron, folic acid, and androgens usually achieves this goal. Some people respond to steroid therapy. Eventually, blood transfusions are required. Anticoagulation therapy may be required to prevent clot formation. A few patients have been successfully treated with a bone marrow transplant.

Expectations (prognosis):

The outcome is varies. Most people do not survive for more than 10 years after diagnosis. Death may be related to complications from blood clot formation (thrombosis).

Complications:

• blood clots
• acute myelogenous leukemia
• iron deficiency anemia
• increased blood cell destruction as a result of treatment with iron, folic acid, and androgens

Calling your health care provider:

Call your health care provider if blood in urine is present.

Call your health care provider if symptoms worsen or do not improve with treatment.

Call your health care provider if new symptoms develop.