General paresis

Treatment:

The goals of treatment are to cure the infection and reduce progression of the disorder.

Treatment of the infection will reduce new nerve damage but will not cure existing damage. Penicillin or other antibiotics such as tetracycline or erythromycin are given to treat the infection. Treatment may be prolonged to ensure that the infection is completely cleared.

A follow-up examination of the cerebrospinal fluid is required to evaluate the effectiveness of antibiotic therapy.

Symptomatic treatment is required for existing neurologic damage. Emergency treatment of seizures may be required. Anticonvulsants such as phenytoin may be needed to control seizures.

Assistance or supervision with such activities as eating and dressing may be needed if patients are unable to care for themselves.

Physical therapy, occupational therapy, or other interventions may be appropriate for people with muscle weakness.

Expectations (prognosis):

Progressive disability is likely. People with late syphilis infections are more prone to the development of other infections and diseases.

Complications:

Complications include the inability to care for oneself, the inability to communicate or interact, injury caused during seizures, and injury from falls (related to unsteady gait).

Calling your health care provider:

Call your health care provider if the symptoms of general paresis are present, particularly if there is a known history of syphilis infection.

Go to the emergency room or call the local emergency number (such as 911) if seizures occur.