Major depression

Alternative names:

depression, major; unipolar depression

Definition:

A recurrent emotional state characterized by feelings of persistent sadness, worthlessness, dejection, loss of hope, and loss of interest in usual activities.

Causes, incidence, and risk factors:

There are multiple causes of depression. In many people, personal loss or severe stress is identified that may interact with a predisposition to depression. The causes may include genetic, familial, biochemical, physical, social, and psychological factors. Major depression occurs in all groups of people. It affects both sexes, with an increased incidence in women. Major depression affects 1 out of 10 Americans at some point in their lives. Major depression is most common in adolescent girls, affecting 5 - 10% of the population. Before puberty, boys and girls seem to be equally vulnerable, about 1 to 2% of the population.