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Liver anatomy
 
Overview   Symptoms   Treatment   Prevention   

Crigler-Najjar syndrome

Alternative names:

glucuronyl transferase deficiency (type I)

Treatment:

Phototherapy is needed on an ongoing basis throughout life. In infants this is done using bilirubin lights (bili lights). Cholestyramine, oral may be given to bind bile salts and remove them from circulation within the liver.

Liver transplantation may be considered for some people with this disorder.

Expectations (prognosis):

Affected individuals who reach adulthood will develop kernicterus despite ongoing treatment. The life expectancy is about 30 years old.

Complications:

Calling your health care provider:

Call for an appointment with your health care provider, about genetic counseling if you are expectant parents and have a family history of Crigler-Najjar.

Call your health care provider if your newborn infant has prolonged jaundice.


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