Adrenoleukodystrophy

Alternative names:

melanodermic leukodystrophy; X-linked adrenoleukodystrophy

Treatment:

Adrenal dysfunction is treated with supplemental steroids (such as cortisone and cortisol).

A specific treatment for adrenoleukodystrophy is not available, but a diet low in long chain fatty acids and the administration of special oils has been demonstrated to lower the plasma levels of long chain fatty acids. These oils are referred to as Lorenzo's oil, after the son of the family who discovered the treatment. This regimen is presently under evaluation for the treatment of adrenoleukodystrophy.

Expectations (prognosis):

The childhood form of adrenoleukodystrophy is a progressive disease that leads to profound disability. The later onset forms are significantly less dangerous.

Complications:

• adrenal crisis
• vegetative state (long-term coma)

Calling your health care provider:

Call your health care provider if your child develops symptoms suggestive of adrenoleukodystrophy or if you have a child with adrenoleukodystrophy who is experiencing increased difficulty.