Alcaptonuria
Symptoms:
Infant/child - family history of alcaptonuria
- urine in diaper may darken after several hours (can become almost black)
Adult - progressive arthritis
- darkening of the ear (from black staining of the cartilage in the ear)
- dark spots on the sclera (white of the eye) and cornea
Signs and tests:
Urinalysis is positive for reducing substance. Further urine testing shows a positive ferric chloride test.
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