Adrenocortical carcinoma

Alternative names:

tumor - adrenal

Symptoms:

Findings suggestive of increased cortisol production:

• flushed rounded face with pudgy cheeks (moon face)
• obesity
• buffalo hump (rounded fatty hump high on the back just below the neck)
• short stature (impaired linear growth, may be less than 5th percentile)

Findings suggestive of virilization:

• increased body hair (hypertrichosis), especially on face
• pubic hair
• acne
• deepening of voice
• enlarged clitoris (girls)

Other:

• hypertension (high blood pressure)
• hemihypertrophy (enlargement of one side of the body)
• hemangioma (rare)

Signs and tests:

• serum cortisol levels
• 17-ketosteroids
• 17-hydroxycorticosteroids
• CT scan of the abdomen (may demonstrate a mass in the adrenal gland)
• abdominal X-ray
• abdominal MRI (may demonstrate a mass in the adrenal gland)