Therapeutic drug levels
Alternative names:
acetaminophen, amikacin, aminophylline, amitriptyline, carbamazepine, chloramphenicol, desipramine, digitoxin, digoxin, disopyramide, ethosuximide, flecainide, gentamicin, imipramine, kanamycin, lidocaine, lithium, methotrexate, nortriptyline, phenobarbital, phenytoin, primidone, procainamide, propranolol, quinidine, salicylate, serum drug levels; TDM; theophylline, therapeutic drug monitoring; tobramycin, valproic acid, serum
Normal values:
Following are some of the drugs that are commonly checked, and their therapeutic levels: - acetaminophen: varies with use
- amikacin: 15 to 25 mcg/ml
- aminophylline: 10 to 20 mcg/ml
- amitriptyline: 120 to 150 ng/ml
- carbamazepine: 5 to 12 mcg/ml
- chloramphenicol: 10 to 20 mcg/ml
- desipramine: 150 to 300 ng/ml
- digitoxin: 15 to 20 ng/ml
- digoxin: 0.8 to 2.0 ng/ml
- disopyramide: 2 to 5 mcg/ml
- ethosuximide: 40 to 100 mcg/ml
- flecainide: 0.2 to 1.0 mcg/ml
- gentamicin: 5 to 10 mcg/ml
- imipramine: 150 to 300 ng/ml
- kanamycin: 20 to 25 mcg/ml
- lidocaine: 1.5 to 5.0 mcg/ml
- lithium: 0.8 to 1.2 mEq/L
- methotrexate: greater than 0.01 mcmol
- nortriptyline: 50 to 150 ng/ml
- phenobarbital: 10 to 30 mcg/ml
- phenytoin: 10 to 20 mcg/ml
- primidone: 5 to 12 mcg/ml
- procainamide: 4 to 10 mcg/ml
- propranolol: 50 to 100 ng/ml
- quinidine: 2 to 5 mcg/ml
- salicylate: 100 to 250 mcg/ml
- theophylline: 10 to 20 mcg/ml
- tobramycin: 5 to 10 mcg/ml
- valproic acid: 50 to 100 mcg/ml
Note: - mcg/ml = microgram per milliliter
- ng/ml = nanogram per milliliter
- mEq/L = milliequivalents per liter
- mcmol = micromole
What abnormal results mean:
Following are some of the drugs that are commonly checked, and their toxic levels: - acetaminophen: greater than 250 mcg/ml
- amikacin: greater than 25 mcg/ml
- aminophylline: greater than 20 mcg/ml
- amitriptyline: greater than 500 ng/ml
- carbamazepine: greater than 12 mcg/ml
- chloramphenicol: greater than 25 mcg/ml
- desipramine: greater than 500 ng/ml
- digitoxin: greater than 25 ng/ml
- digoxin: greater than 2.4 ng/ml
- disopyramide: greater than 5 mcg/ml
- ethosuximide: greater than 100 mcg/ml
- flecainide: greater than 1.0 mcg/ml
- gentamicin: greater than 12 mcg/ml
- imipramine: greater than 500 ng/ml
- kanamycin: greater than 35 mcg/ml
- lidocaine: greater than 5 mcg/ml
- lithium: greater than 2.0 mEq/L
- methotrexate: greater than 10 mcmol over 24-hours
- nortriptyline: greater than 500 ng/ml
- phenobarbital: greater than 40 mcg/ml
- phenytoin: greater than 30 mcg/ml
- primidone: greater than 15 mcg/ml
- procainamide: greater than 16 mcg/ml
- propranolol: greater than 150 ng/ml
- quinidine: greater than 10 mcg/ml
- salicylate: greater than 300 mcg/ml
- theophylline: greater than 20 mcg/ml
- tobramycin: greater than 12 mcg/ml
- valproic acid: greater than 100 mcg/ml
Note: - mcg/ml = microgram per milliliter
- ng/ml = nanogram per milliliter
- mEq/L = milliequivalents per liter
- mcmol = micromole
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