Serum globulin electrophoresis

Alternative names:

globulin electrophoresis (SPEP)

Normal values:

serum globulin: 2.0 to 3.5 g/dl
IgM component: 75 to 175 mg/dl
IgG component: 950 to 1450 mg/dl
IgA component: 160 to 260 mg/dl

Note: g/dl = grams per deciliter; mg/dl = milligrams per deciliter

What abnormal results mean:

Increased gamma globulin proteins may indicate:

• multiple myeloma
• chronic inflammatory disease (for example, rheumatoid arthritis and SLE)
• hyperimmunization
• acute infection
• Waldenstrom's macroglobulinemia

See also immunoelectrophoresis - serum.