Gastric ulcer; benign

Alternative names:

benign gastric ulcer; peptic ulcer; peptic ulcer disease; stomach ulcer; ulcer

Definition:

A sore (ulcer) on the lining of the stomach. Also see duodenal ulcer.

Causes, incidence, and risk factors:

According for the Centers for Disease Control and Prevention, approximately 80% of gastric ulcers are caused by Helicobacter pylori (H. pylori) bacterium. This common, spiral-shaped bacterium can weaken the protective mucus coating of the stomach, allowing acid and bacteria to ulcerate the sensitive lining underneath. About two-thirds of the world's population is infected with H. pylori, but most of those infected do not exhibit symptoms related to the infection. Chronic or long-term use of aspirin or nonsteroidal anti-inflammatory medications (NSAIDs), such as ibuprofen, can also cause gastric ulcers. About 2% to 4% of gastric ulcers are caused by stomach or pancreatic cancer.

Gastric ulcers are not caused by spicy foods or stress.

Risk factors include H. pylori infection, NSAID use, chronic gastritis, group A blood type, and being over age 50. According to the National Institutes of Health, as many as 10% of the population will experience a peptic ulcer (gastric or duodenal) at some point in their lives.