Thyrotoxic periodic paralysis
Alternative names:
periodic paralysis - thyrotoxic
Treatment:
The goals of treatment are relief of acute symptoms and prevention of further attacks. Weakness that involves the muscles used for breathing or swallowing is an emergency situation. Dangerous heart arrhythmias may also occur during attacks.
Potassium that is given during an attack may stop the attack. It is preferred that potassium be given by mouth, but if weakness is severe, intravenous potassium may be necessary. (Note: intravenous potassium should be given only if kidney function is adequate and if the person is monitored in the hospital.)
A diet that is low in carbohydrates and salt may be recommended.
Treatment of the underlying thyroid disorder usually stops attacks.
Beta-blockers may reduce the number and severity of attacks while measures to control hyperthyroidism are occurring.
Acetazolamide, a medications that is effective in attack prevention with familial periodic paralysis, is often ineffective with thyrotoxic periodic paralysis.
Expectations (prognosis):
Chronic attacks will eventually result in progressive muscle weakness that is present even between attacks. Thyrotoxic periodic paralysis responds well to treatment. Treatment of hyperthyroidism may prevent and may even reverse progressive muscle weakness.
Complications:
Calling your health care provider:
Go to the emergency room or call the local emergency number (such as 911) if intermittent muscle weakness occurs, particularly if there is a family history of periodic paralysis or thyroid disorders. Fainting, and difficulty breathing, speaking, or swallowing are among the emergency symptoms.
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