Serum sickness

Treatment:

The goal of treatment is the relief of symptoms.

Topical corticosteroids or other soothing topical (applied to a localized area of the skin) medications may relieve discomfort from itching and rash. Antihistamines may shorten the duration of illness and help to relieve rash and itching. Nonsteroidal anti-inflammatory medications may relieve joint pain. Corticosteroids such as prednisone may be prescribed for severe cases.

Causative medications should be stopped.

Future use of the medication or antiserum should be avoided. Health care providers (such as dentists and hospital personnel) should be advised of drug allergies before treating the patient. Identifying jewelry or cards (such as Medic-Alert or others) may be advised.

Expectations (prognosis):

The symptoms usually resolve within a few days. The antiserum or medication should be avoided in the future.

Complications:

• discomfort
• shock (rare)
• increased risk of anaphylaxis for future exposures to the substance

Calling your health care provider:

Call your health care provider if medication or antiserum has been given within the last 2 weeks and symptoms of serum sickness appear.