Bullous pemphigoid

Definition:

A skin disorder characterized by formation of large blisters.

Causes, incidence, and risk factors:

The blisters of bullous pemphigoid usually appear on the areas of the body that flex or move (flexural areas). About one-third of persons with bullous pemphigoid also develop blisters in the mouth. The disorder may occur in various forms, from no symptoms, to mild redness and irritation, to multiple blisters. The cause is not known, but may be related to immune system disorders.

Bullous pemphigoid typically occurs in elderly persons and is rare in young people. It is characterized by a pattern of exacerbations and remissions. It may be without symptoms for 5 or 6 years, then suddenly flare up.