Wegener's granulomatosis

Alternative names:

midline granulomatosis

Symptoms:

• fever
• bloody discharge from the nose
• pain over the sinuses
• lesions (ulcers, sores, and crusting) in and around opening of the nose
• cough
• bloody sputum
• shortness of breath
• chest pain
• blood in the urine
• conjunctivitis or other eye problems
• rashes
• loss of appetite
• weight loss
• weakness
• fatigue
• joint pains
• wheezing
• coughing up blood

Signs and tests:

• biopsy of abnormal tissue, which may include
  • open lung biopsy
  • upper airway biopsy
  • nasal mucosal biopsy
  • bronchoscopy with transtracheal biopsy

• urinalysis (protein and blood in the urine [proteinuria and hematuria])
• chest X-ray (cavity formation, pulmonary infiltrates)
• bone marrow aspiration (may be done)