Beriberi
Alternative names:
thiamine deficiency; vitamin B1 deficiency
Definition:
A vitamin deficiency disease, caused by a lack of vitamin
B1 (thiamine); the
most significant manifestations are damage to the heart and
nervous system. It is the third most common cause of dementia
in the US.
Causes, incidence, and risk factors:
Beriberi has become almost nonexistent in the United States
since the discovery of its cause, thiamine deficiency. Most
foods are vitamin enriched and a normal diet contains adequate
amounts of thiamine.
Beriberi can appear, however, in breast-fed infants when the
mother has an inadequate intake of thiamine or among people
whose diet includes certain types of fish that produce an
enzyme which inactivates
thiamine.
Early symptoms of beriberi are nonspecific and include fatigue,
irritability, restlessness,
loss of appetite, and
vague abdominal discomfort.
As the disease progresses, patients develop burning sensations,
tingling in the extremities,
and changes in sensation such as numbness.
Patients may develop psychosis.
Heart manifestations are caused by degeneration of the heart
muscle and include heart
failure with shortness
of breath (dyspnea)
and cyanosis (bluish
tinged skin). Neurologic symptoms are caused by degeneration
of the nerve fiber and its insulation (myelin).
Death is generally a result of heart failure.
There are two kinds of beriberi: "dry" and "wet". Dry beriberi
is associated with energy deprivation and inactivity characterized
by mental confusion, peripheral neuropathy, muscular wasting
with loss of function or paralysis of the lower extremities.
Wet beriberi is resultant of high carbohydrate intake along
with strenuous exercise characterized by edema, tachycardia,
pulmonary congestion, and enlarged heart.
Updated Date: 02/09/00
Updated By:J. Gordon Lambert, MD, Associate Medical Director,
Utah Health Informatics and adam.com
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