Cushing's syndrome caused by adrenal tumor

Symptoms:

• moon face (round, red and full)
• buffalo hump (a collection of fat between the shoulders)
• central obesity with protruding abdomen and thin extremities
• weight gain
• weakness
• backache
• headache
• acne or superficial skin infections
• thirst
• increased urination
• purple striations on the skin of the abdomen, thighs, and breasts
• mental changes
• impotence or cessation of menses
• breast development in males

Signs and tests:

Tests to confirm hypercortisolism:

• 24 hour urine for
  • cortisol, urine
  • creatinine-urine

• dexamethasone suppression test
• serial serum (blood tests) to measure cortisol level do not show diurnal variations

Tests to determine cause:

• ACTH is low normal or undetectable
• high-dose dexamethasone suppression test
• abdominal CT may show adrenal mass

Other findings:

• fasting glucose is elevated
• serum potassium may be low

This disease may also alter the results of the following tests:

• estriol-urine
• estriol-serum
• adrenal biopsy
• 17-ketosteroids