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Hereditary angioedema

Definition:

An inherited abnormality of the immune system that causes rapid onset of tissue swelling. Also see angioedema.

Causes, incidence, and risk factors:

Hereditary angioedema is an inherited trait that affects proteins that assist in the destruction of infectious bacteria and play a role in other diseases. People with hereditary angioedema can develop rapid swelling of the hands, feet, limbs, face, intestinal tract, or airway (larynx or trachea). Unlike hives from an allergic reaction, there is usually no itching with hereditary angioedema. Swelling of the gut can cause intestinal cramping. Closure of the airway by swelling can be fatal. Attacks of swelling can become more severe in late childhood and adolescence.


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