CPK isoenzymes

Alternative names:

CK - isoenzymes; creatine kinase - isoenzymes; creatine phosphokinase - isoenzymes

Normal values:

CPK-MM: 0 to 100%
CPK-MB: 0 to 5%
CPK-BB: 0%

What abnormal results mean:

Higher-than-normal CPK-1 levels may indicate:

• brain cancer
• brain injury
• electroconvulsive therapy
• pulmonary infarction (tissue death)
• seizure
• stroke
• subarachnoid hemorrhage

Higher-than-normal CPK-2 levels may indicate:

• cardiac ischemia
• electrical injuries
• heart attack
• post-cardiac defibrillation
• post-cardiac surgery

Just after a heart attack (2 to 3 hours), there is a significant rise in CPK-2 levels. The level increases with the severity of the heart attack. CPK levels remain elevated up to 24-hours after a heart attack.

Higher-than-normal CPK-3 levels may indicate:

• crush injury of a muscle
• multiple IM (intramuscular) injections
• muscular dystrophy
• myositis (muscle inflammation)
• post-electromyography
• recent convulsions
• recent surgery
• rhabdomyolysis
• strenuous exercise

Additional conditions under which the test may be performed:

• pericarditis; post-MI